Protein functional epitopes: hot spots, dynamics and combinatorial libraries.

@article{Ma2001ProteinFE,
  title={Protein functional epitopes: hot spots, dynamics and combinatorial libraries.},
  author={Buyong Ma and Haim J. Wolfson and Ruth Nussinov},
  journal={Current opinion in structural biology},
  year={2001},
  volume={11 3},
  pages={364-9}
}
Recent studies increasingly point to the importance of structural flexibility and plasticity in proteins, highlighting the evolutionary advantage. There are an increasing number of cases in which given, presumably specific, binding sites have been shown to bind a range of ligands with different compositions and shapes. These studies have also revealed that evolution tends to find convergent solutions for stable intermolecular associations, largely via conservation of polar residues as hot spots… CONTINUE READING

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