Protein friction limits diffusive and directed movements of kinesin motors on microtubules.

@article{Bormuth2009ProteinFL,
  title={Protein friction limits diffusive and directed movements of kinesin motors on microtubules.},
  author={Volker Bormuth and Vladimir Varga and Jonathon Howard and Erik Sch{\"a}ffer},
  journal={Science},
  year={2009},
  volume={325 5942},
  pages={870-3}
}
Friction limits the operation of macroscopic engines and is critical to the performance of micromechanical devices. We report measurements of friction in a biological nanomachine. Using optical tweezers, we characterized the frictional drag force of individual kinesin-8 motor proteins interacting with their microtubule tracks. At low speeds and with no energy source, the frictional drag was related to the diffusion coefficient by the Einstein relation. At higher speeds, the frictional drag… CONTINUE READING
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