Protein folding state-dependent sorting at the Golgi apparatus

  title={Protein folding state-dependent sorting at the Golgi apparatus},
  author={D. Hellerschmied and Yevgeniy V. Serebrenik and L. Shao and George M. Burslem and C. Crews},
  journal={Molecular Biology of the Cell},
  pages={2296 - 2308}
In eukaryotic cells, organelle-specific protein quality control (PQC) is critical for maintaining cellular homeostasis. Despite the Golgi apparatus being the major protein processing and sorting site within the secretory pathway, how it contributes to PQC has remained largely unknown. Using different chemical biology-based protein unfolding systems, we reveal the segregation of unfolded proteins from folded proteins in the Golgi. Quality control (QC) substrates are subsequently exported in… Expand
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