Protein folding simulations with genetic algorithms and a detailed molecular description.

Abstract

We have explored the application of genetic algorithms (GA) to the determination of protein structure from sequence, using a full atom representation. A free energy function with point charge electrostatics and an area based solvation model is used. The method is found to be superior to previously investigated Monte Carlo algorithms. For selected fragments… (More)

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Cite this paper

@article{Pedersen1997ProteinFS, title={Protein folding simulations with genetic algorithms and a detailed molecular description.}, author={J. T. Pedersen and John Moult}, journal={Journal of molecular biology}, year={1997}, volume={269 2}, pages={240-59} }