Protein folding revisited. A polypeptide chain at the folding – misfolding – nonfolding cross-roads: which way to go?

@article{Uversky2003ProteinFR,
  title={Protein folding revisited. A polypeptide chain at the folding – misfolding – nonfolding cross-roads: which way to go?},
  author={Vladimir N. Uversky},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2003},
  volume={60},
  pages={1852-1871}
}
The structure-function paradigm claims that a specific function of a protein is determined by its unique and rigid three-dimensional (3D) structure. Thus, following its biosynthesis on the ribosome, a protein must fold to be functional. This idea represents one of the cornerstones of modern biology. Numerous cases when, due to the effect of environmental factors or because of genetic defects (mutations), a polypeptide chain has lost its capability to gain a proper functional 3D structure (i.e… CONTINUE READING

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