Protein folding during cotranslational translocation in the endoplasmic reticulum.

Abstract

To test how far into the protein-conducting channel of the translocon complex a nascent polypeptide domain must move before it can fold, we analyzed the folding of in vitro translated products of truncated mRNAs encoding the Semliki Forest virus capsid protease domain (Cp) during translocation into microsomes. Cp folded when the C-terminal linker connecting… (More)

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Cite this paper

@article{Kowarik2002ProteinFD, title={Protein folding during cotranslational translocation in the endoplasmic reticulum.}, author={Michael Kowarik and Stephanie Kueng and Bruno Martoglio and Ari Helenius}, journal={Molecular cell}, year={2002}, volume={10 4}, pages={769-78} }