Protein folding and misfolding

@article{Dobson2003ProteinFA,
  title={Protein folding and misfolding},
  author={C. Dobson},
  journal={Nature},
  year={2003},
  volume={426},
  pages={884-890}
}
  • C. Dobson
  • Published 2003
  • Chemistry, Medicine
  • Nature
  • The manner in which a newly synthesized chain of amino acids transforms itself into a perfectly folded protein depends both on the intrinsic properties of the amino-acid sequence and on multiple contributing influences from the crowded cellular milieu. Folding and unfolding are crucial ways of regulating biological activity and targeting proteins to different cellular locations. Aggregation of misfolded proteins that escape the cellular quality-control mechanisms is a common feature of a wide… CONTINUE READING
    3,745 Citations

    Figures and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    8 – Misfolded proteins
    • 2
    Converging concepts of protein folding in vitro and in vivo
    • 981
    • PDF
    Protein folding and diseases.
    • C. Lee, M. Yu
    • Chemistry, Medicine
    • Journal of biochemistry and molecular biology
    • 2005
    • 37
    • PDF
    Pathways of chaperone-mediated protein folding in the cytosol
    • 1,074
    • PDF
    Protein folding in the cytoplasm and the heat shock response.
    • 302
    • PDF
    Protein folding on the ribosome.
    • 111
    • PDF
    Amyloid fibrils: the eighth wonder of the world in protein folding and aggregation.
    • I. Lednev
    • Biology, Medicine
    • Biophysical journal
    • 2014
    • 22
    Principles of protein misfolding.
    • M. Ramirez-Alvarado
    • Chemistry, Medicine
    • Progress in molecular biology and translational science
    • 2008
    • 4
    The Generic Nature of Protein Folding and Misfolding
    • 17

    References

    SHOWING 1-10 OF 87 REFERENCES
    Defective protein folding as a basis of human disease.
    • 526
    Kinetic role of early intermediates in protein folding.
    • 273
    A surprising simplicity to protein folding
    • 675
    • PDF
    The structural basis of protein folding and its links with human disease.
    • C. Dobson
    • Biology, Medicine
    • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    • 2001
    • 844
    Protein folding and misfolding: a paradigm of self–assembly and regulation in complex biological systems
    • 112
    Enzymes that catalyse the restructuring of proteins.
    • 195
    Kinetic partitioning of protein folding and aggregation
    • 376
    Understanding protein folding via free-energy surfaces from theory and experiment.
    • 450
    • PDF
    Protein Folding and Unfolding at Atomic Resolution
    • 441
    • PDF