Protein folding and misfolding

@article{Dobson2003ProteinFA,
  title={Protein folding and misfolding},
  author={Christopher M. Dobson},
  journal={Nature},
  year={2003},
  volume={426},
  pages={884-890}
}
  • C. Dobson
  • Published 18 December 2003
  • Medicine, Chemistry
  • Nature
The manner in which a newly synthesized chain of amino acids transforms itself into a perfectly folded protein depends both on the intrinsic properties of the amino-acid sequence and on multiple contributing influences from the crowded cellular milieu. Folding and unfolding are crucial ways of regulating biological activity and targeting proteins to different cellular locations. Aggregation of misfolded proteins that escape the cellular quality-control mechanisms is a common feature of a wide… Expand

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