Protein folding and misfolding

  title={Protein folding and misfolding},
  author={C. Dobson},
  • C. Dobson
  • Published 2003
  • Chemistry, Medicine
  • Nature
  • The manner in which a newly synthesized chain of amino acids transforms itself into a perfectly folded protein depends both on the intrinsic properties of the amino-acid sequence and on multiple contributing influences from the crowded cellular milieu. Folding and unfolding are crucial ways of regulating biological activity and targeting proteins to different cellular locations. Aggregation of misfolded proteins that escape the cellular quality-control mechanisms is a common feature of a wide… CONTINUE READING
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