Protein farnesylation and disease

@article{Novelli2011ProteinFA,
  title={Protein farnesylation and disease},
  author={Giuseppe Novelli and Maria Rosaria D'Apice},
  journal={Journal of Inherited Metabolic Disease},
  year={2011},
  volume={35},
  pages={917-926}
}
Prenylation consists of the addition of an isoprenoid group to a cysteine residue located near the carboxyl terminal of a protein. This enzymatic posttranslational modification is important for the maturation and processing of proteins. Both processes are necessary to mediate protein-protein and membrane-protein associations, in addition to regulating the localisation and function of proteins. The severe phenotype of animals deficient in enzymes involved in both prenylation and maturation… 
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