• DOI:10.1146/ANNUREV.BIOCHEM.74.082803.133029
Corpus ID: 7483470

Protein families and their evolution-a structural perspective.

@article{Orengo2005ProteinFA,
  title={Protein families and their evolution-a structural perspective.},
  author={C. Orengo and J. Thornton},
  journal={Annual review of biochemistry},
  year={2005},
  volume={74},
  pages={
          867-900
        }
}

• C. Orengo, J. Thornton
• Published 2005
• Biology, Medicine
• Annual review of biochemistry

We can now assign about two thirds of the sequences from completed genomes to as few as 1400 domain families for which structures are known and thus more ancient evolutionary relationships established. About 200 of these domain families are common to all kingdoms of life and account for nearly 50% of domain structure annotations in the genomes. Some of these domain families have been very extensively duplicated within a genome and combined with different domain partners giving rise to different… Expand

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