Protein-facilitated folding of group II intron ribozymes.

@article{Fedorova2010ProteinfacilitatedFO,
  title={Protein-facilitated folding of group II intron ribozymes.},
  author={Olga Fedorova and Amanda Solem and Anna M Pyle},
  journal={Journal of molecular biology},
  year={2010},
  volume={397 3},
  pages={
          799-813
        }
}
Multiple studies hypothesize that DEAD-box proteins facilitate folding of the ai5gamma group II intron. However, these conclusions are generally inferred from splicing kinetics, and not from direct monitoring of DEAD-box protein-facilitated folding of the intron. Using native gel electrophoresis and dimethyl sulfate structural probing, we monitored Mss-116-facilitated folding of ai5gamma intron ribozymes and a catalytically active self-splicing RNA containing full-length intron and short exons… CONTINUE READING

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Mss116p: a DEAD-box protein facilitates RNA folding.

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