Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer.

@article{Moul1996ProteinEO,
  title={Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer.},
  author={Judd W. Moul and M C Bettencourt and Isabell A. Sesterhenn and Fathollah K Mostofi and David G. Mcleod and Sudhir K. Srivastava and John J. Bauer},
  journal={Surgery},
  year={1996},
  volume={120 2},
  pages={159-66; discussion 166-7}
}
BACKGROUND Protein expression in the primary tumor of the tumor suppressor gene p53 and the proto-oncogene bcl-2 have been shown to be prognostic biomarkers of cancer recurrence after radical prostatectomy in patients with clinically localized prostate cancer. Cancer cell proliferation as measured by immunohistochemical markers such as the MIB-1 antibody for Ki-67 has recently been suggested to be of prognostic value in prostate cancer. The goal of this study was to determine the clinical use… CONTINUE READING