Protein expression of carcinoembryonic antigen cell adhesion molecules in benign and malignant melanocytic skin lesions.

@article{Gambichler2009ProteinEO,
  title={Protein expression of carcinoembryonic antigen cell adhesion molecules in benign and malignant melanocytic skin lesions.},
  author={Thilo Gambichler and Sarah Grothe and Sebastian Rotterdam and Peter Josef Altmeyer and Alexander Kreuter},
  journal={American journal of clinical pathology},
  year={2009},
  volume={131 6},
  pages={782-7}
}
Dysregulation of cell adhesion molecules is associated with progression of malignant melanoma. Immunohistologic study of benign nevi (BN), dysplastic nevi (DN), and primary superficial spreading melanoma (SSM) was performed for carcinoembryonic antigen (CEA) and CEA cell adhesion molecule-1 (CEACAM1) using monoclonal antibodies. We investigated BN (n = 42), DN (n = 22), thin SSM (n = 21), and thick SSM (n = 21). CEA expression in melanomas and DN was significantly increased compared with BN… CONTINUE READING