Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.

@article{Fridberg2007ProteinEA,
  title={Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.},
  author={Marie Fridberg and Anna Servin and Lola Anagnostaki and Johan Linderoth and Mattias Berglund and Ola S{\"o}derberg and Gunilla Enblad and Anders Ros{\'e}n and Tomas M. Mustelin and Mats Jerkeman and Jenny Liao Persson and Anette Gj{\"o}rloff Wingren},
  journal={Leukemia & lymphoma},
  year={2007},
  volume={48 11},
  pages={2221-32}
}
Patients diagnosed with diffuse large B-cell lymphoma (DLBCL) show varying responses to conventional therapy, and this might be contributed to the differentiation stage of the tumor B-cells. The aim of the current study was to evaluate a panel of kinases (ZAP70, PKC-beta I and II and phosphorylated PKB/Akt) and phosphatases (PTEN, SHP1 and SHP2) known to be frequently deregulated in lymphoid malignancies. De novo DLBCL cases were divided into two subgroups, the germinal center (GC) group (14/28… CONTINUE READING