Protein evolution in yeast transcription factor subnetworks

@inproceedings{Wang2010ProteinEI,
  title={Protein evolution in yeast transcription factor subnetworks},
  author={Yong Wang and Eric A. Franzosa and Xiang-Sun Zhang and Yu Xia},
  booktitle={Nucleic acids research},
  year={2010}
}
When averaged over the full yeast protein-protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased negative selection. However, genome-wide analysis of protein evolution in the subnetworks of associations involving yeast transcription factors (TFs) reveals that TF hubs do not tend to evolve significantly more slowly than TF non-hubs. This result holds for all four major types… CONTINUE READING