Protein engineering of toluene monooxygenases for synthesis of chiral sulfoxides.

@article{Feingersch2008ProteinEO,
  title={Protein engineering of toluene monooxygenases for synthesis of chiral sulfoxides.},
  author={Roi Feingersch and Janna Shainsky and Thomas K. Wood and Ayelet Fishman},
  journal={Applied and environmental microbiology},
  year={2008},
  volume={74 5},
  pages={1555-66}
}
Enantiopure sulfoxides are valuable asymmetric starting materials and are important chiral auxiliaries in organic synthesis. Toluene monooxygenases (TMOs) have been shown previously to catalyze regioselective hydroxylation of substituted benzenes and phenols. Here we show that TMOs are also capable of performing enantioselective oxidation reactions of aromatic sulfides. Mutagenesis of position V106 in the alpha-hydroxylase subunit of toluene ortho-monooxygenase (TOM) of Burkholderia cepacia G4… CONTINUE READING

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