Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region.

@article{Shin2006ProteinDI,
  title={Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region.},
  author={Joo-ho Shin and Talin Gulesserian and Emmanuelle Verger and Jean-Maurice Delabar and Gert Lubec},
  journal={Journal of proteome research},
  year={2006},
  volume={5 1},
  pages={44-53}
}
Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear-conditioned memory defects and were observed to be dysregulated in human fetal DS.