Protein dynamism and evolvability.

@article{Tokuriki2009ProteinDA,
  title={Protein dynamism and evolvability.},
  author={Nobuhiko Tokuriki and Dan S. Tawfik},
  journal={Science},
  year={2009},
  volume={324 5924},
  pages={
          203-7
        }
}
The traditional view that proteins possess absolute functional specificity and a single, fixed structure conflicts with their marked ability to adapt and evolve new functions and structures. We consider an alternative, "avant-garde view" in which proteins are conformationally dynamic and exhibit functional promiscuity. We surmise that these properties are the foundation stones of protein evolvability; they facilitate the divergence of new functions within existing folds and the evolution of… CONTINUE READING

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