Protein dynamics viewed by hydrogen exchange.

  title={Protein dynamics viewed by hydrogen exchange.},
  author={John J. Skinner and Woon Ki Lim and Sabrina B{\'e}dard and Ben E. Black and S. Walter Englander},
  journal={Protein science : a publication of the Protein Society},
  volume={21 7},
To examine the relationship between protein structural dynamics and measurable hydrogen exchange (HX) data, the detailed exchange behavior of most of the backbone amide hydrogens of Staphylococcal nuclease was compared with that of their neighbors, with their structural environment, and with other information. Results show that H-bonded hydrogens are protected from exchange, with HX rate effectively zero, even when they are directly adjacent to solvent. The transition to exchange competence… CONTINUE READING

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Hydrogen exchange mass spectrometry special issue

  • J Engen, Jorgensen TJD
  • Int J Mass Spectrom
  • 2011

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