Protein dynamics and the immunological evolution of molecular recognition.

@article{Jimenez2004ProteinDA,
  title={Protein dynamics and the immunological evolution of molecular recognition.},
  author={Ralph Jimenez and Georgina To'a Salazar and J. M. Yin and Taiha Joo and Floyd E Romesberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 11},
  pages={
          3803-8
        }
}
While it is accepted that protein flexibility plays a role in protein folding, catalysis, and molecular recognition, few techniques are capable of the rigorous measurement of protein motions required to quantify flexibility. Three-pulse photon echo shift spectroscopy can be used to measure the time scale of protein motions, and we have used this technique, along with steady-state spectroscopy and binding and structural data, to examine the immunological evolution of protein flexibility in an… CONTINUE READING

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