Protein docking using a genetic algorithm.

@article{Gardiner2001ProteinDU,
  title={Protein docking using a genetic algorithm.},
  author={Eleanor J. Gardiner and Peter Willett and Peter J. Artymiuk},
  journal={Proteins},
  year={2001},
  volume={44 1},
  pages={44-56}
}
A genetic algorithm (GA) for protein-protein docking is described, in which the proteins are represented by dot surfaces calculated using the Connolly program. The GA is used to move the surface of one protein relative to the other to locate the area of greatest surface complementarity between the two. Surface dots are deemed complementary if their normals are opposed, their Connolly shape type is complementary, and their hydrogen bonding or hydrophobic potential is fulfilled. Overlap of the… CONTINUE READING

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