Protein disulfide isomerase.

  title={Protein disulfide isomerase.},
  author={Bonney M. Wilkinson and Hiram F. Gilbert},
  journal={Biochimica et biophysica acta},
  volume={1699 1-2},
During the maturation of extracellular proteins, disulfide bonds that chemically cross-link specific cysteines are often added to stabilize a protein or to join it covalently to other proteins. Disulfide formation, which requires a change in the covalent structure of the protein, occurs as the protein folds into its three-dimensional structure. In the eukaryotic endoplasmic reticulum and in the bacterial periplasm, an elaborate system of chaperones and folding catalysts ensure that disulfides… CONTINUE READING
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