Protein disulfide isomerase is a multifunctional regulator of estrogenic status in target cells.

@article{Fu2008ProteinDI,
  title={Protein disulfide isomerase is a multifunctional regulator of estrogenic status in target cells.},
  author={Xinmiao Fu and Pan Wang and Bao Ting Zhu},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2008},
  volume={112 1-3},
  pages={127-37}
}
Earlier studies showed that protein disulfide isomerase (PDI), a well-known protein folding catalyst and a molecular chaperone, can bind estrogens and may also directly interact with the estrogen receptor (ER). In this study, we sought to determine the biological functions of these intriguing properties of PDI. We showed that PDI can function as a high-capacity intracellular 17beta-estradiol (E(2))-binding protein that increases the concentration and accumulation of E(2) in live cells. The… CONTINUE READING

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