Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation.

@article{Reinhardt2008ProteinDI,
  title={Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation.},
  author={Christoph Reinhardt and Marie-Luise von Bruehl and Davit Manukyan and Lenka Grahl and Michael Lorenz and Berid Altmann and Silke Dlugai and Sonja Hess and Ildiko Konrad and Lena Orschiedt and Nigel Mackman and Lloyd W Ruddock and Steffen Massberg and Bernd Engelmann},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 3},
  pages={1110-22}
}
The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF activation are largely undefined. Here we show that the oxidoreductase protein disulfide isomerase (PDI) directly promotes TF-dependent fibrin production during thrombus formation in vivo. After endothelial denudation of mouse carotid arteries, PDI was released at the injury site from adherent platelets… CONTINUE READING