Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.

@article{Larson1996ProteinDB,
  title={Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.},
  author={R. C. Larson and Isabelle Lavenir and Teresa A Larson and Richard D. Baer and Alan J Warren and I A Wadman and Kerri A. Nottage and Terence H Rabbitts},
  journal={The EMBO journal},
  year={1996},
  volume={15 5},
  pages={1021-7}
}
The LMO2 and TAL1 genes were first identified via chromosomal translocations and later found to encode proteins that interact during normal erythroid development. Some T cell leukaemia patients have chromosomal abnormalities involving both genes, implying that LMO2 and TAL1 act synergistically to promote tumorigenesis after their inappropriate co-expression… CONTINUE READING