Protein design on computers. Five new proteins: Shpilka, grendel, fingerclasp, leather, and aida

@article{Sander1992ProteinDO,
  title={Protein design on computers. Five new proteins: Shpilka, grendel, fingerclasp, leather, and aida},
  author={Chris Sander and Gerrit Vriend and Fernando Bazan and Amnon Horovitz and Haruki Nakamura and Luis Ribas and Alexei V. Finkelstein and Andrew Lockhart and Rainer Merkl and L. Jeanne Perry and Stephen C Emery and Christine Gaboriaud and Cara B. Marks and John Moult and Christophe L. M. J. Verlinde and Mark Eberhard and Arne Elofsson and Tim J. P. Hubbard and Lynne Regan and Jay Banks and Roberto Jappelli and Arthur M. Lesk and Anna Tramontano},
  journal={Proteins: Structure},
  year={1992},
  volume={12}
}
What is the current state of the art in protein design? This question was approached in a recent two‐week protein design workshop sponsored by EMBO and held at the EMBL in Heidelberg. The goals were to test available design tools and to explore new design strategies. Five novel proteins were designed: Shpilka, a sandwich of two four‐stranded β‐sheets, a scaffold on which to explore variations in loop topology; Grendel, a four‐helical membrane anchor, ready for fusion to water‐soluble functional… 
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