Protein design of an HIV-1 entry inhibitor.

@article{Root2001ProteinDO,
  title={Protein design of an HIV-1 entry inhibitor.},
  author={Michael J Root and Michael S Kay and Peter S. Kim},
  journal={Science},
  year={2001},
  volume={291 5505},
  pages={
          884-8
        }
}
Human immunodeficiency virus type-1 (HIV-1) membrane fusion is promoted by the formation of a trimer-of-hairpins structure that brings the amino- and carboxyl-terminal regions of the gp41 envelope glycoprotein ectodomain into close proximity. Peptides derived from the carboxyl-terminal region (called C-peptides) potently inhibit HIV-1 entry by binding to the gp41 amino-terminal region. To test the converse of this inhibitory strategy, we designed a small protein, denoted 5-Helix, that binds the… CONTINUE READING

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