Protein design by binary patterning of polar and nonpolar amino acids.

  title={Protein design by binary patterning of polar and nonpolar amino acids.},
  author={Luke H. Bradley and Yinan Wei and Peter P Thumfort and Christine Wurth and Michael H Hecht},
  journal={Methods in molecular biology},
The design of large libraries of well-folded de novo proteins is a powerful approach toward the ultimate goal of producing proteins with novel structures and functions for use in industry or medicine. A method for library design that incorporates both rational design and combinatorial diversity relies on the "binary patterning" of polar and nonpolar amino acids. Binary patterning is based on the premise that the appropriate arrangement of polar and nonpolar residues can direct a polypeptide… CONTINUE READING
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