Protein depletion and replenishment in mice: different roles of muscle and liver.

@article{Scornik1997ProteinDA,
  title={Protein depletion and replenishment in mice: different roles of muscle and liver.},
  author={Oscar A. Scornik and Scott K. Howell and Violeta Botbol},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1997},
  volume={273 6},
  pages={E1158-E1167}
}
Fully grown male CD-1 mice, fed a protein-free diet for 3 days, received 1 g of starch with or without 300 mg casein by intragastric intubation. We surveyed the acute effects of these nutrients on protein synthesis in all tissues (by extrapolating to infinity the incorporation of radioactive leucine after its injection in massive doses) and protein degradation in skeletal muscle and liver (by the accumulation of bestatin-induced peptide intermediates). Muscle proteolysis was the major source of… CONTINUE READING

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