Protein delivery with transportans is mediated by caveolae rather than flotillin-dependent pathways.

@article{Slik2009ProteinDW,
  title={Protein delivery with transportans is mediated by caveolae rather than flotillin-dependent pathways.},
  author={Pille S{\"a}{\"a}lik and K{\"a}rt Padari and Aira Niinep and Annely Lorents and Mats Hansen and Eija Jokitalo and Ulo Langel and Margus Pooga},
  journal={Bioconjugate chemistry},
  year={2009},
  volume={20 5},
  pages={877-87}
}
Delivery of large bioactive cargoes into cells with the help of cell-penetrating peptides (CPPs) is mostly based on endocytic processes. Here we map the cellular pathways used by transportan and transportan 10 (TP10) for protein transduction in HeLa cells. CPP-mediated cellular delivery is often suggested to be lipid-raft-dependent; therefore, we used flotillin-1, caveolin, Rab5, and PI3P as markers to elucidate the involvement of these particular endosomal pathways in the protein uptake… CONTINUE READING