Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy.

  title={Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy.},
  author={Honglin Luo and Jerry Wong and Brian S. Wong},
  journal={Cardiovascular research},
  volume={85 2},
The primary intracellular protein degradation systems, including the ubiquitin-proteasome and the lysosome pathways, have been emerging as central regulators of viral infectivity, inflammation, and viral pathogenicity. Viral myocarditis is an inflammatory disease of the myocardium caused by virus infection in the heart. The disease progression of viral myocarditis occurs in three distinct stages: acute viral infection, immune cell infiltration, and cardiac remodelling. Growing evidence suggests… CONTINUE READING


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