Protein degradation in the aging organism.

  title={Protein degradation in the aging organism.},
  author={Walter F. Ward},
  journal={Progress in molecular and subcellular biology},
  • Walter F. Ward
  • Published 2002 in Progress in molecular and subcellular biology
It is now generally accepted that protein degradation declines with age but a mechanism of action for this decline has not yet been delineated. Although intracellular and extracellular proteins can enter multiple pathways of degradation, there primarily appears to be two final mediators of this degradation, the lysosome and the proteasome. Studies on the effects of age on lysosomal function suggest that, if anything, lysosomal enzyme activity increases with age (Ward 2000). The peptidase… CONTINUE READING

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