Protein degradation in DNA damage response.

  title={Protein degradation in DNA damage response.},
  author={Ilektra Kouranti and Anne Peyroche},
  journal={Seminars in cell & developmental biology},
  volume={23 5},
DNA damage is a major threat to genome integrity. To reduce its deleterious effects, cells have developed coordinated responses, collectively referred to as the "DNA damage response" pathway (DDR). In multicellular organisms, the DDR pathway has a critical role in preventing tumorigenesis, which accounts for the wide use of drugs targeting DDR factors in anti-cancer therapy. Post-translational modifications such as phosphorylation, ubiquitylation, acetylation, sumoylation are integral part of… CONTINUE READING

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