Protein degradation: Prime time for PROTACs.


Fourteen years ago, heterobifunctional molecules referred to as proteolysis targeting chimeras (PROTACs) were introduced as promoters of cellular protein degradation1. PROTACs contain one moiety that binds an E3 linked to another that binds a desired cellular target protein (Fig. 1). This induced proximity results in ubiquitination of the target followed by… (More)
DOI: 10.1038/nchembio.1887


1 Figure or Table