Protein deficiency balance as a predictor of clinical outcome in hereditary spherocytosis.

@article{Rocha2005ProteinDB,
  title={Protein deficiency balance as a predictor of clinical outcome in hereditary spherocytosis.},
  author={Sara M Rocha and Irene Rebelo and El{\'i}sio Costa and Cristina Catarino and Lu{\'i}s Gustavo Belo and Elisabeth Molnar Bayer Castro and Jos{\'e} Manuel Cabeda and Jos{\'e} Barbot and Alexandre Quintanilha and Alice Santos-Silva},
  journal={European journal of haematology},
  year={2005},
  volume={74 5},
  pages={374-80}
}
Vertical and horizontal interactions between membrane constituents account for integrity, strength and deformability of the erythrocyte. Disruption of vertical interactions caused by membrane protein deficiencies in hereditary spherocytosis (HS), favor membrane vesiculation with development of spherocytic cells. Our aim was to evaluate the hematological and clinical presentation of HS according to the type and amount of protein deficiency. We studied 81 Portuguese individuals, 71 belonging to… CONTINUE READING