Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72.

@article{Meriin1999ProteindamagingSA,
  title={Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72.},
  author={Anatoli B Meriin and Julia A. Yaglom and Vladimir L. Gabai and Soula Ganiatsas and Dick D. Mosser and Leonard Zon and Michael Yu Sherman},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 4},
  pages={2547-55}
}
Various stresses activate the c-Jun N-terminal kinase (JNK), which is involved in the regulation of many aspects of cellular physiology, including apoptosis. Here we demonstrate that in contrast to UV irradiation, heat shock causes little or no stimulation of the JNK-activating kinase SEK1, while knocking out the SEK1 gene completely blocks heat-induced JNK activation. Therefore, we tested whether heat shock activates JNK via inhibition of JNK dephosphorylation. The rate of JNK… CONTINUE READING

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