Protein crystal structures: quicker, cheaper approaches
@article{Collins1975ProteinCS, title={Protein crystal structures: quicker, cheaper approaches}, author={Douglas M. Collins and F. A. Cotton and E. E. Jun. Hazen and Edgar F. Meyer and Carl N. Morimoto}, journal={Science}, year={1975}, volume={190}, pages={1047 - 1053} }
The use of x-ray diffraction methods to study crystals of biological macromolecules dates from 1934, when Bernal and Crowfoot (1) found that the diffraction patterns from crystals of the proteolytic enzyme pepsin were, in Hodgkin's words (2), "rich and full of detail." The potential for revealing the precise molecular structure of protein molecules inherent in such diffraction patterns remained unrealized until 1954, when M. F. Perutz, who had devoted his early career to the effort, showed that…
23 Citations
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