Protein crystal quality oriented disulfide bond engineering

Abstract

A disulfide bond that formed between the thiol groups of two spatially close cysteine residues is essential for protein folding, stability, and function (Creighton et al., 1995) (Fass, 2012). Driven by conformational entropy, native disulfide bonds stabilize the conformation of protein molecules (Dill, 1990), while removal of native disulfides usually… (More)
DOI: 10.1007/s13238-017-0482-7

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1 Figure or Table