Protein crosslinking in assembly and remodelling of extracellular matrices: the role of transglutaminases.

@article{Aeschlimann2000ProteinCI,
  title={Protein crosslinking in assembly and remodelling of extracellular matrices: the role of transglutaminases.},
  author={Daniel Aeschlimann and Vilmos A. Thomazy},
  journal={Connective tissue research},
  year={2000},
  volume={41 1},
  pages={1-27}
}
Transglutaminases form a family of proteins that have evolved for specialized functions such as protein crosslinking in haemostasis, semen coagulation, or keratinocyte cornified envelope formation. In contrast to the other members of this protein family, tissue transglutaminase is a multifunctional enzyme apparently involved in very disparate biological processes. By virtue of its reciprocal Ca2+-dependent crosslinking activity or GTP-dependent signal transducing activity, tissue… CONTINUE READING

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