Corpus ID: 33559148

Protein cross-linking properties of the antitumor agent inosine dialdehyde (NSC-118994).

@article{Cysyk1976ProteinCP,
  title={Protein cross-linking properties of the antitumor agent inosine dialdehyde (NSC-118994).},
  author={R. Cysyk and R. Adamson},
  journal={Cancer treatment reports},
  year={1976},
  volume={60 5},
  pages={
          563-70
        }
}
Inosine dialdehyde (IdA), a new antitumor agent presently undergoing clinical evaluation in man, possesses two aldehyde groups that form stable complexes with a variety of biologic molecules containing amino groups. Complex formation of IdA with lysine, glycine, histidine, or bovine serum albumin (BSA) greatly reduces the cytotoxicity of IdA against L1210 leukemia in vitro. Complexes of IdA and BSA exhibit molecular weights ranging from 69,000 to greater than 800,000 as determined by Sephadex G… Expand
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