Protein cross-linking mediated by tissue transglutaminase correlates with the maturation of extracellular matrices during lung development.

@article{Schittny1997ProteinCM,
  title={Protein cross-linking mediated by tissue transglutaminase correlates with the maturation of extracellular matrices during lung development.},
  author={Johannes C. Schittny and Mats Paulsson and Claudio Vallan and Peter H. Burri and Noemi Kedei and Daniel Aeschlimann},
  journal={American journal of respiratory cell and molecular biology},
  year={1997},
  volume={17 3},
  pages={
          334-43
        }
}
At birth, the mammalian lung is still immature. The alveoli are not yet formed and the interairspace walls contain two capillary layers which are separated by an interstitial core. After alveolarization (first 2 postnatal weeks in rats) the alveolar septa mature: their capillary layers merge, the amount of connective tissue decreases, and the mature lung parenchyma is formed (second and third week). During the first 3 wk of life the role of tissue transglutaminase (tTG) was studied in rat lung… 
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