Protein consequences of the Col2a1 C-propeptide mutation in the chondrodysplastic Dmm mouse.

@article{Fernandes2003ProteinCO,
  title={Protein consequences of the Col2a1 C-propeptide mutation in the chondrodysplastic Dmm mouse.},
  author={Russell J. Fernandes and Robert E. Seegmiller and Whitney Nelson and David R. Eyre},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2003},
  volume={22 5},
  pages={449-53}
}
The Disproportionate micromelia (Dmm) mouse has a three nucleotide deletion in Col2a1 in the region encoding the C-propeptide which results in the substitution of one amino acid, Asn, for two amino acids, Lys-Thr. Western blot and immunohistochemical analyses failed to detect type II collagen in the cartilage matrix of the homozygous mice and showed reduced… CONTINUE READING