Protein complexes regulating Arp2/3-mediated actin assembly.

  title={Protein complexes regulating Arp2/3-mediated actin assembly.},
  author={Theresia Stradal and Giorgio Scita},
  journal={Current opinion in cell biology},
  volume={18 1},
Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin filaments, which can be catalysed by a limited number of proteins and protein complexes. Among these, Arp2/3 complex and formins are the best studied. Arp2/3-complex activity is controlled through signalling-dependent association with nucleation-promoting factors, such as the WASP/WAVE family proteins. A common theme for these molecules, which is well established for WAVEs but is only just beginning to… CONTINUE READING
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