Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin–AP-1-coated carrier biogenesis at the TGN

@article{Anitei2010ProteinCC,
  title={Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin–AP-1-coated carrier biogenesis at the TGN},
  author={Mihaela Anitei and Christoph Stange and Irina Parshina and Thorsten Baust and Annette Schenck and Graça Raposo and Tomas Kirchhausen and Bernard Hoflack},
  journal={Nature Cell Biology},
  year={2010},
  volume={12},
  pages={330-340}
}
Actin dynamics is a tightly regulated process involved in various cellular events including biogenesis of clathrin-coated, AP-1 (adaptor protein 1)-coated transport carriers connecting the trans-Golgi network (TGN) and the endocytic pathway. However, the mechanisms coordinating coat assembly, membrane and actin remodelling during post-TGN transport remain poorly understood. Here we show that the Arf1 (ADP-ribosylation factor 1) GTPase synchronizes the TGN association of clathrin–AP-1 coats and… CONTINUE READING

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