Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum.

@article{Chugh2013ProteinCD,
  title={Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum.},
  author={Monika Chugh and V. Sundararaman and Saravanan Arun Kumar and V. Siva Nagi Reddy and Waseem Ahmed Siddiqui and Kenneth D. Stuart and Pawan Malhotra},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 14},
  pages={5392-7}
}
Malaria parasites use hemoglobin (Hb) as a major nutrient source in the intraerythrocytic stage, during which heme is converted to hemozoin (Hz). The formation of Hz is essential for parasite survival, but to date, the underlying mechanisms of Hb degradation and Hz formation are poorly understood. We report the presence of a ∼200-kDa protein complex in the food vacuole that is required for Hb degradation and Hz formation. This complex contains several parasite proteins, including falcipain 2/2… CONTINUE READING
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