Protein circlets as sex pilus subunits.

  title={Protein circlets as sex pilus subunits.},
  author={Markus Kalkum and Ralf Eisenbrandt and Erich Lanka},
  journal={Current protein & peptide science},
  volume={5 5},
The largest circular protein structures discovered define a class of transfer proteins acting in bacterial conjugation and type IV secretion. Proteins ranging from 73 to 78 residues with head-to-tail peptide bonds constitute the major subunit of conjugative pili of some type IV secretion systems. Their plasmid-encoded precursors are enzymatically processed and cyclized before being assembled into pili. These extra-cellular surface filaments mediate physical contact between donor and recipient… CONTINUE READING

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