Protein-calcium phosphate nanocomposites: Benchmarking protein loading via physical and chemical modifications against co-precipitation

@inproceedings{Kollath2015ProteincalciumPN,
  title={Protein-calcium phosphate nanocomposites: Benchmarking protein loading via physical and chemical modifications against co-precipitation},
  author={Vinayaraj Ozhukil Kollath and Steven Mullens and Jan Luyten and Karl Traina and Rudi Cloots},
  year={2015}
}
The low protein loading capacity of commercially available calcium phosphate (CaP) is a major impediment in effectively using this inorganic material as a protein carrier despite its recognized biocompatibility. In this study, nanocomposites of CaP and BSA were prepared by carefully designed precipitation methods in aqueous media. In the first co-precipitation method (CaP–BSA-1), calcium and phosphate precursors were simultaneously added to the protein solution matrix and in the second method… CONTINUE READING

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