Protein breakdown in muscle from burned rats is blocked by insulin-like growth factor i and glycogen synthase kinase-3beta inhibitors.

@article{Fang2005ProteinBI,
  title={Protein breakdown in muscle from burned rats is blocked by insulin-like growth factor i and glycogen synthase kinase-3beta inhibitors.},
  author={C H Fang and B G Li and J. Howard James and J King and Amy R. Evenson and Glenn D. Warden and Per Olof Hasselgren},
  journal={Endocrinology},
  year={2005},
  volume={146 7},
  pages={3141-9}
}
We reported previously that IGF-I inhibits burn-induced muscle proteolysis. Recent studies suggest that activation of the phosphotidylinositol 3-kinase (PI3K)/Akt signaling pathway with downstream phosphorylation of Forkhead box O transcription factors is an important mechanism of IGF-I-induced anabolic effects in skeletal muscle. The potential roles of other mechanisms in the anabolic effects of IGF-I are less well understood. In this study we tested the roles of mammalian target of rapamycin… CONTINUE READING