Protein-bound polysaccharide K suppresses tumor fibrosis in gastric cancer by inhibiting the TGF-β signaling pathway

@inproceedings{Shinbo2015ProteinboundPK,
  title={Protein-bound polysaccharide K suppresses tumor fibrosis in gastric cancer by inhibiting the TGF-β signaling pathway},
  author={Toshifumi Shinbo and Sachio Fushida and Tomoya Tsukada and Shinichi Harada and Jun Kinoshita and Katsunobu Oyama and Koichi Okamoto and Itasu Ninomiya and Hiroyuki Hitachinaka Takamura and Hirohisa Kitagawa and Takeshi Fujimura and Masakazu Yashiro and Kousei Hirakawa and Tetsuo Ohta},
  booktitle={Oncology reports},
  year={2015}
}
Peritoneal carcinomatosis (PC) is the most frequent metastatic pattern of gastric cancer and its prognosis is extremely poor. PC is characterized by rich fibrosis and the development of obstructive disorders such as ileus, jaundice and hydronephrosis. Epithelial-mesenchymal transition (EMT) is one of the major causes of tissue fibrosis and transforming growth factor β (TGF-β) has a pivotal function in the progression of EMT. Protein-bound polysaccharide K (PSK) is a biological response modifier… CONTINUE READING

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