Protein biophysics explains why highly abundant proteins evolve slowly.

@article{Serohijos2012ProteinBE,
  title={Protein biophysics explains why highly abundant proteins evolve slowly.},
  author={Adrian W. R. Serohijos and Zilvinas Rimas and Eugene I. Shakhnovich},
  journal={Cell reports},
  year={2012},
  volume={2 2},
  pages={249-56}
}
The consistent observation across all kingdoms of life that highly abundant proteins evolve slowly demonstrates that cellular abundance is a key determinant of protein evolutionary rate. However, other empirical findings, such as the broad distribution of evolutionary rates, suggest that additional variables determine the rate of protein evolution. Here, we report that under the global selection against the cytotoxic effects of misfolded proteins, folding stability (ΔG), simultaneous with… CONTINUE READING
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