Protein biogenesis machinery is a driver of replicative aging in yeast

@inproceedings{Janssens2015ProteinBM,
  title={Protein biogenesis machinery is a driver of replicative aging in yeast},
  author={Georges E Janssens and Anne C Meinema and Javier Gonz{\'a}lez and Justina C. Wolters and Alexander Schmidt and Victor Guryev and Rainer Bischoff and Ernst C. Wit and Liesbeth M Veenhoff and Matthias Heinemann and Karsten Weis},
  booktitle={eLife},
  year={2015}
}
An integrated account of the molecular changes occurring during the process of cellular aging is crucial towards understanding the underlying mechanisms. Here, using novel culturing and computational methods as well as latest analytical techniques, we mapped the proteome and transcriptome during the replicative lifespan of budding yeast. With age, we found primarily proteins involved in protein biogenesis to increase relative to their transcript levels. Exploiting the dynamic nature of our data… CONTINUE READING

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Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae

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